The Financial Times (London)

Much to learn about stem cells

By Clive Cookson

Published: June 26 2009 03:00 | Last updated: June 26 2009 03:00

A study published online by Nature today shows how much scientists still have to learn about stem cells. Researchers at the Carnegie Institution in Baltimore were surprised to find that different genes are responsible in embryos and adults for making muscle stem cells.

Working with genetically engineered mice, they discovered that the two key genes involved in embryonic muscle formation remain active until about three weeks after birth. In adults, different genes are involved in repairing damaged or injured muscles.

"We are just beginning to learn the basics of stem cell biology, and there are many surprises," says Allan Spradling, director of Carnegie's embryology department. "This work illustrates the importance of carrying out basic research using animal models before rushing into the clinic with half-baked therapies."

Chris Mason, professor of regenerative medicine at University College London, adds: "This paper perfectly illustrates the absolute necessity for research scientists to be actively encouraged to work with all the different cell types that are available. This includes human embryonic, fetal, adult and induced pluripotent stem (iPS) cells."

Copyright The Financial Times Limited 2009